List of Publications
2024
DeIsidroGomez2024
- AUTHOR = F.P. de Isidro-Gómez and J.L. Vilas and P. Losana and J.M. Carazo and C.O.S. Sorzano
- TITLE = A deep learning approach to the automatic detection of alignment errors in cryo-electron tomographic reconstructions
- JOURNAL = Journal of Structural Biology
- VOLUME = 216
- YEAR = 2024
- NUMBER = 1
- URL = https://www.sciencedirect.com/science/article/pii/S1047847723001193
- ISSN = 1047-8477
- DOI = https://doi.org/10.1016/j.jsb.2023.108056
2023
Strelak2023
- AUTHOR = Střelák, David and Marchán, Daniel and Carazo, José María and S. Sorzano, Carlos O.
- TITLE = Performance and Quality Comparison of Movie Alignment Software for Cryogenic Electron Microscopy
- JOURNAL = Micromachines
- VOLUME = 14
- YEAR = 2023
- NUMBER = 10
- ARTICLE-NUMBER = 1835
- URL = https://www.mdpi.com/2072-666X/14/10/1835
- ISSN = 2072-666X
- DOI = https://doi.org/10.3390/mi14101835
Fernandez-Gimenez2023a
- title = A new algorithm for particle weighted subtraction to eliminate signals from unwanted components in Single Particle Analysis
- journal = Journal of Structural Biology
- volume = 215
- number = 4
- year = 2023
- issn = 1047-8477
- doi = https://doi.org/10.1016/j.jsb.2023.108024
- url = https://www.sciencedirect.com/science/article/pii/S1047847723000874
- author = E. Fernández-Giménez, M. Martínez, R. Marabini, D. Strelak, R. Sánchez-García, J.M. Carazo and C.O.S. Sorzano
Fernandez-Gimenez2023b
- title = Local defocus estimation in Single Particle Analysis in Cryo-Electron Microscopy
- journal = Journal of Structural Biology
- volume = 215
- number = 4
- year = 2023
- issn = 1047-8477
- doi = https://doi.org/10.1016/j.jsb.2023.108030
- url = https://www.sciencedirect.com/science/article/pii/S104784772300093X
- author = E. Fernández-Giménez, J.M. Carazo and C.O.S. Sorzano
Vilas2023
- AUTHOR = Vilas JL and Tagare HD
- TITLE = A simple and intuitive measurement of directional resolution anisotropy of cryoEM maps
- JOURNAL = Nature Methods
- VOLUME = X
- YEAR = 2023
- NUMBER = X
- ARTICLE-NUMBER = in press
- URL = https://github.com/I2PC/xmipp/wiki/FSO^^Fourier-Shell-Occupancy
2021
sanchez2021deepemhancer
- title = DeepEMhancer: a deep learning solution for cryo-EM volume post-processing,
- author = Sanchez-Garcia, Ruben and Gomez-Blanco, Josue and Cuervo, Ana and Carazo, Jose Maria and Sorzano, Carlos Oscar S and Vargas, Javier,
- journal = Communications biology,
- volume = 4,
- number = 1,
- pages = 874,
- year = 2021,
- publisher = Nature Publishing Group UK London
fernandez2021cryo
- title = Cryo-EM density maps adjustment for subtraction, consensus and sharpening,
- author = Fernandez-Gimenez, E and Martinez, M and Sanchez-Garcia, R and Marabini, R and Ramirez-Aportela, E and Conesa, P and Carazo, JM and Sorzano, COS,
- journal = Journal of Structural Biology,
- volume = 213,
- number = 4,
- pages = 107780,
- year = 2021,
- publisher = Elsevier
Fernandez-Gimenez2021
- title = Cryo-EM density maps adjustment for subtraction consensus and sharpening
- journal = Journal of Structural Biology
- volume = 213
- number = 4
- year = 2021
- issn = 1047-8477
- doi = https://doi.org/10.1016/j.jsb.2021.107780
- url = https://www.sciencedirect.com/science/article/pii/S104784772100085X
- author = E. Fernández-Giménez and M. Martínez and R. Sánchez-García and R. Marabini and E. Ramírez-Aportela and P. Conesa and J.M. Carazo and C.O.S. Sorzano
Strelak2021
- AUTHOR = Strelak David and Jiménez-Moreno Amaya and Vilas José L. and Ramírez-Aportela Erney and Sánchez-García Ruben and Maluenda David and Vargas Javier and Herreros David and Fernández-Giménez Estrella and de Isidro-Gómez Federico P. and Horacek Jan and Myska David and Horacek Martin and Conesa Pablo and Fonseca-Reyna Yunior C. and Jiménez Jorge and Martínez Marta and Harastani Mohamad and Jonić Slavica and Filipovic Jiri and Marabini Roberto and Carazo José M. and Sorzano Carlos O. S.
- TITLE = Advances in Xmipp for Cryo–Electron Microscopy: From Xmipp to Scipion
- JOURNAL = Molecules
- VOLUME = 26
- YEAR = 2021
- NUMBER = 20
- ARTICLE-NUMBER = 6224
- URL = https://www.mdpi.com/1420-3049/26/20/6224
- PubMedID = 34684805
- ISSN = 1420-3049
- DOI = https://doi.org/10.3390/molecules26206224
2020
strelak2020flexalign
- AUTHOR = Střelák David and Filipovič Jiří and Jiménez-Moreno Amaya and Carazo Jose María and Sánchez Sorzano Carlos Óscar
- TITLE = FlexAlign: An Accurate and Fast Algorithm for Movie Alignment in Cryo-Electron Microscopy
- JOURNAL = Electronics
- VOLUME = 9
- YEAR = 2020
- NUMBER = 6
- ARTICLE-NUMBER = 1040
- URL = http://www.mdpi.com/2079-9292/9/6/1040
- ISSN = 2079-9292
- DOI = http://doi.org/10.3390/electronics9061040
2018
Vilas2018
- title = MonoRes: Automatic and Accurate Estimation of Local Resolution for Electron Microscopy Maps
- author = Vilas J. L. and et al
- year = 2018
- journal = Structure
- pages = 337-344
- volume = 26
- doi = 10.1016/j.str.2017.12.018
- url = http://doi.org/10.1016/j.str.2017.12.018
2016
Vilas2016
- title = Fast and automatic identification of particle tilt pairs based on Delaunay triangulation.
- author = Vilas J. L. and Navas J. and Gomez-Blanco J. and de la Rosa-Trevin J. M. and Melero and Peschiera I. and Ferlenghi. I and Cuenca J. and Marabini R. and Carazo J. M. and Vargas J. and Sorzano C. O. S.
- journal = Journal of Structural Biology
- year = 2016
- pages = 525-533
- volume = 196
- doi = http://dx.doi.org/10.1016/j.jsb.2016.10.007
- url = http://www.sciencedirect.com/science/article/pii/S104784771630212X
Sorzano2016
- title = StructMap: Elastic distance analysis of electron microscopy maps for studying conformational changes
- journal = Biophysical J.
- volume = 110
- number =
- pages = 1753-1765
- year = 2016
- note =
- issn =
- doi = http://doi.org/10.1016/j.bpj.2016.03.019
- url = http://doi.org/10.1016/j.bpj.2016.03.019
- author = C.O.S. Sorzano A.L. Álvarez-Cabrera M. Kazemi J.M. Carazo S. Jonic
- keywords =
2015
Sorzano2015
- author = Sorzano C. O. S. and Vargas J. and de la Rosa-Trevin J. M. and Oton J. and Alvarez-Cabrera A. L. and Abrishami V. and Sesmero E. and Marabini R. and Carazo J. M.
- title = A Statistical approach to the initial volume problem in Single Particle Analysis by Electron Microscopy
- journal = J. Structural Biology
- year = 2015
- volume = 189
- pages = 213-219
- doi = http://dx.doi.org/10.1016/j.jsb.2015.01.009
Abrishami2015
- title = Alignment of direct detection device micrographs using a robust Optical Flow approach
- journal = Journal of Structural Biology
- volume = 189
- number = 3
- pages = 163 - 176
- year = 2015
- note =
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/j.jsb.2015.02.001
- url = http://www.sciencedirect.com/science/article/pii/S1047847715000313
- author = Vahid Abrishami and Javier Vargas and Xueming Li and Yifan Cheng and Roberto Marabini and Carlos Óscar Sánchez Sorzano and José María Carazo
- keywords = Direct detection devices
- keywords = Beam induced motion
- keywords = Single particle analysis
- keywords = Electron microscopy
Sorzano2015b
- title = Cryo-EM and the elucidation of new macromolecular structures: Random Conical Tilt revisited.
- author = Sorzano C O S. and Alcorlo M. and de la Rosa-Trevín J. M. and Melero R. and Foche I. and Zaldívar-Peraza A. and del Cano L. and Vargas J. and Abrishami V. and Otón J. and Marabini R. and Carazo J. M.
- journal = Scientific Reports
- year = 2015
- pages = 14290
- volume = 5
- doi = http://dx.doi.org/10.1038/srep14290
- url = http://dx.doi.org/10.1038/srep14290
2014
Vargas2014
- author = Vargas Javier and Álvarez-Cabrera Ana-Lucia and Marabini Roberto and Carazo Jose M. and Sorzano C. O. S.
- title = Efficient initial volume determination from electron microscopy images of single particles
- volume = 30
- number = 20
- pages = 2891-2898
- year = 2014
- doi = http://dx.doi.org/10.1093/bioinformatics/btu404
- abstract =Motivation: Structural information of macromolecular complexes provides key insights into the way they carry out their biological functions. The reconstruction process leading to the final 3D map requires an approximate initial model. Generation of an initial model is still an open and challenging problem in single-particle analysis.Results: We present a fast and efficient approach to obtain a reliable low-resolution estimation of the 3D structure of a macromolecule without any a priori knowledge addressing the well-known issue of initial volume estimation in the field of single-particle analysis. The input of the algorithm is a set of class average images obtained from individual projections of a biological object at random and unknown orientations by transmission electron microscopy micrographs. The proposed method is based on an initial non-lineal dimensionality reduction approach which allows to automatically selecting representative small sets of class average images capturing the most of the structural information of the particle under study. These reduced sets are then used to generate volumes from random orientation assignments. The best volume is determined from these guesses using a random sample consensus (RANSAC) approach. We have tested our proposed algorithm which we will term 3D-RANSAC with simulated and experimental data obtaining satisfactory results under the low signal-to-noise conditions typical of cryo-electron microscopy.Availability: The algorithm is freely available as part of the Xmipp 3.1 package [http://xmipp.cnb.csic.es].Contact: jvargas@cnb.csic.esSupplementary information: Supplementary data are available at Bioinformatics online.
- URL = http://bioinformatics.oxfordjournals.org/content/30/20/2891.abstract
- eprint = http://bioinformatics.oxfordjournals.org/content/30/20/2891.full.pdf+html
- journal = Bioinformatics
Sorzano2014
- title = Outlier detection for single particle analysis in Electron Microscopy
- author = Sorzano C. O. S. and Vargas J. and de la Rosa-Trevín J. M. and Zaldívar-Peraza A. and Otón J. and Abrishami V. and Foche I. and Marabini R. and Caffarena G. and Carazo J. M.
- journal = Proc. Intl. Work-Conference on Bioinformatics and Biomedical Engineering IWBBIO
- year = 2014
- pages = 950
- doi = http://biocomp.cnb.csic.es/-coss/Articulos/Sorzano2014.pdf
Jin2014
- title = Iterative Elastic 3D-to-2D Alignment Method Using Normal Modes for Studying Structural Dynamics of Large Macromolecular Complexes
- journal = Structure
- volume = 22
- pages = 1 - 11
- year = 2014
- doi = http://dx.doi.org/10.1016/j.str.2014.01.004
- url = http://www.ncbi.nlm.nih.gov/pubmed/24508340
- author = Jin Q. and Sorzano C. O. S. and de la Rosa-Trevín J. M. and Bilbao-Castro J. R. and Núñez-Ramirez R. and Llorca O. and Tama F. and Jonic S.
- keywords = Normal mode analysis NMA
Vargas2014a
- title = Particle alignment reliability in single particle electron cryomicroscopy: a general approach
- journal = Scientific reports
- volume =
- number =
- pages =
- year = 2014
- note =
- issn =
- doi = http://dx.doi.org/10.1038/srep21626
- url = http://dx.doi.org/10.1038/srep21626
- author = Vargas
- keywords = Validation
Marabini2014a
- title = CTF Challenge: Result summary
- journal = J. Structural Biology
- volume =
- number =
- pages =
- year = 2015
- note =
- issn =
- doi = http://doi.org/10.1016/j.jsb.2015.04.003
- url = http://doi.org/10.1016/j.jsb.2015.04.003
- author = Marabini
- keywords = Contrast transfer function
2013
Sorzano2013
- title = Semiautomatic High-Throughput High-Resolution Protocol for Three-Dimensional Reconstruction of Single Particles in Electron Microscopy
- booktitle = Nanoimaging
- year = 2013
- isbn = 978-1-62703-136-3
- volume = 950
- journal = Methods in Molecular Biology
- editor = Sousa Alioscka A. and Kruhlak Michael J.
- doi = http://dx.doi.org/10.1007/978-1-62703-137-0_11
- publisher = Humana Press
- keywords = Single particle analysis; Electron microscopy; Image processing; 3D reconstruction; Workflows
- author = Sorzano C.O.S. and de la Rosa-Trevín J.M. and Otón J. and Vega J.J. and Cuenca J. and Zaldívar-Peraza A. and Gómez-Blanco J. and Vargas J. and Quintana A. and Marabini Roberto and Carazo José María
- pages = 171-193
Vargas2013a
- author = Vargas J. and Otón J. and Marabini R. and Jonic S. and de la
Rosa-Trevín J. M. and et.al.
- title = FASTDEF: Fast defocus and astigmatism estimation for high-throughput
transmission electron microscopy.
- journal = J. Structural Biology
- doi = http://dx.doi.org/10.1016/j.jsb.2012.12.006
- year = 2013
- volume = 181
- pages = 136^148
- number = 2
- month = Feb
Vargas2013b
- title = Particle quality assessment and sorting for automatic and semiautomatic particle-picking techniques
- journal = J. Structural Biology
- volume = 183
- number = 3
- pages = 342 - 353
- year = 2013
- note =
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/j.jsb.2013.07.015
- url = http://www.sciencedirect.com/science/article/pii/S1047847713001950
- author = J. Vargas and V. Abrishami and R. Marabini and J.M. de la Rosa-Trevín and A. Zaldivar and J.M. Carazo and C.O.S. Sorzano
- keywords = Electron microscopy Particle picking Machine learning Single particle analysis
Abrishami2013
- author = Abrishami V. and Zaldívar-Peraza A. and de la Rosa-Trevín J. M. and Vargas J. and Otón J. and Marabini R. and Shkolnisky Y. and Carazo J. M. and Sorzano C. O. S.
- title = A pattern matching approach to the automatic selection of particles from low-contrast electron micrographs
- volume = 29
- number = 19
- pages = 2460-2468
- year = 2013
- doi = http://dx.doi.org/10.1093/bioinformatics/btt429
- url = http://bioinformatics.oxfordjournals.org/content/29/19/2460.abstract
- journal = Bioinformatics
delaRosaTrevin2013
- title = Xmipp 3.0: An improved software suite for image processing in electron microscopy
- journal = JSB
- volume = 184
- number = 2
- pages = 321 - 328
- year = 2013
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/j.jsb.2013.09.015
- url = http://www.sciencedirect.com/science/article/pii/S1047847713002566
- author = de la Rosa-Trevín J.M. and Oton J. and R. Marabini and A. Zaldívar and J. Vargas and J.M. Carazo and Sorzano C.O.S.
- keywords = Electron microscopy Single particles analysis Image processing Software package
Nogales2013
- title=3DEM Loupe: analysis of macromolecular dynamics using structures from electron microscopy
- author=Nogales-Cadenas R. and Jonic S. and Tama F. and Arteni A. A. and Tabas-Madrid D. and V\'azquez M. and Pascual-Montano A. and Sorzano C. O. S.
- journal=Nucleic acids research
- year=2013
- publisher=Oxford Univ Press
- doi=http://dx.doi.org/10.1093/nar/gkt385
2010
Sorzano2010a
- title = A clustering approach to multireference alignment of single-particle projections in electron microscopy
- journal = Journal of Structural Biology
- volume = 171
- number = 2
- pages = 197 - 206
- year = 2010
- note =
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/j.jsb.2010.03.011
- url = http://www.sciencedirect.com/science/article/pii/S1047847710000882
- author = C.O.S. Sorzano and J.R. Bilbao-Castro and Y. Shkolnisky and M. Alcorlo and R. Melero and G. Caffarena-Fernández and M. Li and G. Xu and R. Marabini and J.M. Carazo
- keywords = Single-particle analysis 2D analysis Multireference analysis Electron microscopy
2009
Scheres2009b
- author = Scheres Sjors H W. and Carazo José María
- title = Introducing robustness to maximum-likelihood refinement of electron-microscopy
- data.
- journal = Acta Crystallogr D Biol Crystallogr
- year = 2009
- volume = 65
- pages = 672^678
- number = Pt 7
- month = Jul
- doi = http://dx.doi.org/10.1107/S0907444909012049
- url = http://dx.doi.org/10.1107/S0907444909012049
- keywords = Algorithms; Cryoelectron Microscopy; Escherichia coli chemistry;
Likelihood Functions; Models Molecular; Peptide Elongation Factor
G chemistry/ultrastructure; Protein Structure Tertiary
Scheres2009c
- author = Scheres Sjors H W. and Melero Roberto and Valle Mikel and Carazo José María
- title = Averaging of Electron Subtomograms and Random Conical Tilt Reconstructions through Likelihood Optimization
- journal = Structure
- year = 2009
- volume = 17
- pages = 1563^1572
- number = 12
- month = Dec
- doi = http://dx.doi.org/10.1016/j.str.2009.10.009
Sorzano2009d
- title = Effects of the downsampling scheme on three-dimensional electron microscopy of single particles
- journal = Proc. of IEEE Workshop on Intelligent Signal Processing
- pages = 175-179
- year = 2009
- note =
- issn = 978-1-4244-5059-6
- doi = http://dx.doi.org/10.1109/WISP.2009.5286563
- url = http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=5286563
- author = Sorzano C. O. S. and Iriarte-Ruiz A. and Marabini R. and Carazo J. M.
- keywords = Downsampling Single Particles Electron microscopy
2007
Sorzano2007a
- Title = Fast robust and accurate determination of transmission electron microscopy contrast transfer function
- Author = Sorzano C. O. S. and Jonic S. and N\'u\\-nez-Ram\'irez R. and Boisset N. and Carazo J. M.
- Journal = J. Structural Biology
- Year = 2007
- Pages = 249^262
- Volume = 160
- doi = http://dx.doi.org/10.1016/j.jsb.2007.08.013
- url = http://www.sciencedirect.com/science/article/pii/S104784770700202X
Scheres2007a
- author = Scheres Sjors H. W. and Haixiao Gao and Mikel Valle and Gabor T Herman and Paul P B Eggermont and et.al.
- title = Disentangling conformational states of macromolecules in 3D-EM through likelihood optimization.
- journal = Nature Methods
- year = 2007
- volume = 4
- pages = 27^29
- number = 1
- month = Jan
- doi = http://dx.doi.org/10.1038/nmeth992
- keywords = Antigens Polyomavirus Transforming; Escherichia coli; Image Processing Computer-Assisted; Imaging Three-Dimensional; Likelihood Functions; Microscopy Electron; Models Molecular; Protein Conformation; Ribosomes; Sensitivity and Specificity; Simian virus 40
Scheres2007b
- author = Scheres Sjors H. W. and Núñez-Ramírez Rafael and Gómez-Llorente
- Yacob and San Martín Carmen and Eggermont Paul P B. and Carazo
- José María
- title = Modeling experimental image formation for likelihood-based classification
- of electron microscopy data.
- journal = Structure
- year = 2007
- volume = 15
- pages = 1167^1177
- number = 10
- month = Oct
- doi = http://dx.doi.org/10.1016/j.str.2007.09.003
- url = http://dx.doi.org/10.1016/j.str.2007.09.003
- keywords = Algorithms; Antigens Polyomavirus Transforming chemistry/ultrastructure;
Archaeal Proteins chemistry/ultrastructure; Cryoelectron Microscopy
methods/statistics /&/ numerical data; DNA Helicases chemistry/ultrastructure;
Escherichia coli metabolism; Imaging Three-Dimensional; Likelihood
Functions; Models Molecular; Models Statistical; Protein Conformation;
Ribosomes chemistry/ultrastructure
2005
Scheres2005a
- title = Maximum-likelihood Multi-reference Refinement for Electron Microscopy Images Journal=J. Mol. Biol.
- volume = 348
- number = 1
- pages = 139 - 149
- year = 2005
- issn = 0022-2836
- doi = http://dx.doi.org/10.1016/j.jmb.2005.02.031
- url = http://www.sciencedirect.com/science/article/pii/S0022283605001932
- author = Scheres Sjors H.W. and Valle Mikel and Rafael Núñez and Carlos O.S. Sorzano and Roberto Marabini and Gabor T. Herman and Jose-Maria Carazo
- keywords = maximum-likelihood multi-reference refinement single-particles 2D-alignment classification
Scheres2005b
- author = Scheres Sjors H.W. and Valle Mikel and Carazo José-María
- title = Fast maximum-likelihood refinement of electron microscopy images.
- journal = Bioinformatics
- year = 2005
- volume = 21 Suppl 2
- pages = ii243–ii244
- month = Sep
- doi = http://dx.doi.org/10.1093/bioinformatics/bti1140
- url = http://dx.doi.org/10.1093/bioinformatics/bti1140
- keywords = Algorithms; Cryoelectron Microscopy methods; Image Enhancement methods; Image Interpretation Computer-Assisted methods; Imaging Three-Dimensional methods; Likelihood Functions; Reproducibility of Results; Sensitivity and Specificity
Jonic2005
- title = Spline-based image-to-volume registration for three-dimensional electron microscopy
- journal = Ultramicroscopy
- volume = 103
- number = 4
- pages = 303 - 317
- year = 2005
- issn = 0304-3991
- doi = http://dx.doi.org/10.1016/j.ultramic.2005.02.002
- url = http://www.sciencedirect.com/science/article/pii/S0304399105000173
- author = Jonic S. and C.O.S. Sorzano and P. Thevenaz and C. El-Bez and S. De Carlo and M. Unser
- keywords = 2D/3D registration Splines 3DEM Angular assignment
2004
Sorzano2004b
- title = A multiresolution approach to orientation assignment in 3D electron microscopy of single particles
- journal = JSB
- volume = 146
- number = 3
- pages = 381 - 392
- year = 2004
- note =
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/j.jsb.2004.01.006
- url = http://www.sciencedirect.com/science/article/pii/S1047847704000073
- author = Sorzano C.O.S. and S. Jonic and C. El-Bez and J.M. Carazo and S. De Carlo and P. Thevenaz and M. Unser
2002
PascualMontano2002
- title = Quantitative self-organizing maps for clustering electron tomograms
- journal = JSB
- volume = 138
- number = 1-2
- pages = 114 - 122
- year = 2002
- note =
- issn = 1047-8477
- doi = http://dx.doi.org/10.1016/S1047-8477(02)00008-4
- url = http://www.sciencedirect.com/science/article/pii/S1047847702000084
- author = Pascual-Montano A and K.A. Taylor and H. Winkler and R.D. Pascual-Marqui and J.-M. Carazo
- keywords = Classification Electron tomography Image processing Neural networks Self-organizing maps Probability density function Kernel functions Actin Myosin Muscle proteins
2001
PascualMontano2001
- title = A Novel Neural Network Technique for Analysis and Classification of \\EM\\ Single-Particle Images
- journal = JSB
- volume = 133
- number = 2 - 3
- pages = 233 - 245
- year = 2001
- issn = 1047-8477
- doi = http://dx.doi.org/10.1006/jsbi.2001.4369
- url = http://www.sciencedirect.com/science/article/pii/S1047847701943692
- author = Pascual-Montano A and L.E Donate and M Valle and M Bárcena and R.D Pascual-Marqui and J.M Carazo
- keywords = classification cryo-EM image processing neural networks self-organizing maps probability density function kernel functions
2000
Pascual2000
- title = Mapping and fuzzy classification of macromolecular images using self-organizing neural networks
- journal = Ultramicroscopy
- volume = 84
- number = 1-2
- pages = 85 - 99
- year = 2000
- note =
- issn = 0304-3991
- doi = http://dx.doi.org/10.1016/S0304-3991(00)00022-X
- url = http://www.sciencedirect.com/science/article/pii/S030439910000022X
- author = Pascual-Montano A and Montserrat Bárcena and J.J Merelo and José-María Carazo
- keywords = Image processing Cluster analysis Neural networks Self-organizing maps Fuzzy logic